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MELITTIN

Product Name
MELITTIN
CAS No.
20449-79-0
Chemical Name
MELITTIN
Synonyms
C11198;forapin;forapine;melitten;MELITTIN;MELLITIN;melittini;melittin(major);beevenommelittin;honeybeemelittin
CBNumber
CB4388272
Molecular Formula
C131H229N39O31
Formula Weight
2846.46
MOL File
20449-79-0.mol
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MELITTIN Property

alpha 
D21 -89.52° (c = 0.409)
Density 
1.39
storage temp. 
-20°C
solubility 
Soluble to 1 mg/ml in 20% acetonitrile
form 
White to faint tan powder.
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
InChIKey
VDXZNPDIRNWWCW-JFTDCZMZSA-N
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36-45-36/37/39
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
OS3965000
F 
10-21
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M4171
Product name
Melittin
Purity
≥97% (HPLC), synthetic
Packaging
250μg
Price
$511
Updated
2024/03/01
Sigma-Aldrich
Product number
M2272
Product name
Melittin from honey bee venom
Purity
≥85% (HPLC)
Packaging
1mg
Price
$83.3
Updated
2024/03/01
Sigma-Aldrich
Product number
M2272
Product name
Melittin from honey bee venom
Purity
≥85% (HPLC)
Packaging
5mg
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
17494
Product name
Melittin
Packaging
500μg
Price
$107
Updated
2023/06/20
Cayman Chemical
Product number
17494
Product name
Melittin
Packaging
5mg
Price
$796
Updated
2023/06/20
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MELITTIN Chemical Properties,Usage,Production

Uses

Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions.

Uses

Melittin from honey bee venom has been used:

  • In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
  • To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
  • As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.

Definition

ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active com onent of bee venom.

General Description

Chemical structure: peptide

Biochem/physiol Actions

Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death.

storage

Store at -20°C

MELITTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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MELITTIN Suppliers

China 155 Europe 2 France 1 Germany 1 India 1 Switzerland 1 United Kingdom 7 United States 14 Global 182
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View Lastest Price from MELITTIN manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Melittin 20449-79-0
Price
US $30.00/box
Min. Order
1box
Purity
98%
Supply Ability
2000kg
Release date
2024-03-21
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Melittin 20449-79-0
Price
US $50.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg/week
Release date
2024-04-24
Henan Tengmao Chemical Technology Co. LTD
Product
Melittin 20449-79-0
Price
US $110.00-90.00/kilogram
Min. Order
1kilogram
Purity
99%
Supply Ability
10 tons/per week
Release date
2023-12-08

20449-79-0, MELITTINRelated Search:

PROPOLIS EXTRACT FROM PENNSYLVANIA 4-NITRO-3-(OCTANOYLOXY)BENZOIC ACID MELITTIN Honey CECROPIN A (1-8)-MELITTIN A (3-9) AMIDE,CECROPIN A (1-7)-MELITTIN A (2-9) AMIDE,CECROPIN A-MELITTIN HYBRID PEPTIDE CECROPIN A (1-8)-MELITTIN (1-18) AMIDE MELITTIN,MELITTIN (FREE ACID) MELITTIN SYNTHETIC >99% BEE VENOM POLYPE PTIDE MELITTIN(MELLITIN) MELITTIN,MELITTIN (NATURAL),melittin- (5-aminopentanoyl)melittin (4-aminobutanoyl)melittin Melittin b BIOTINYL-MELITTIN cecropin A(1-8)melittin(1-2) cecropin A(1-7)melittin(2-9) cecropin A(1-8)melittin(1-18) melittin(8-26)

  • beevenommelittin
  • forapin
  • forapine
  • Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Gln-L-Gln-NH2
  • Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Glu(NH2)-L-Glu(NH2)-NH2
  • GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
  • C11198
  • melittin from honey bee venom
  • BeeVenomCrystalline
  • BeeVenomLyophilised
  • Melittin, ≥97% (HPLC)
  • honeybeemelittin
  • melitten
  • melittin(apiscerana)
  • melittin(honeybee)
  • melittin(major)
  • melittini
  • MELITTIN (NATURAL)
  • MELITTIN
  • MELLITIN
  • GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
  • GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2
  • H-GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2
  • MELITTIN USP/EP/BP
  • Melittin (honeybee) (9CI, ACI)
  • L-Glutamamide, glycyl-L-isoleucylglycy
  • 20449-79-0
  • C131H229N39O31
  • Biochemicals and Reagents
  • Calcium Antagonists
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Chelators
  • Intracellular Calcium Signaling
  • Proteomics and Protein Expression
  • Protein Analysis
  • Protein Sequencing
  • Standards for Protein Sequencing
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Enzymes, Inhibitors, and Substrates
  • BioChemical
  • Amino Acids
  • Calcium Antagonists
  • Cell Signaling and Neuroscience
  • Intracellular Calcium Signaling